Calcium, mitochondria, and Alzheimer’s

Published May 12, 2020

It’s common knowledge (well, sort of) that Alzheimer’s patients have a buildup of amyloid beta plaques in their brain tissue, but every treatment targeting the plaque has failed. Neurologists at Mass General have some new information — and a potential new target for treatment: high levels of calcium in the mitochondria of mice with Alzheimer’s. What this means: Instead of targeting the amyloid beta plaques, it might be better to target the “neuronal mitochondrial calcium uniporter” — the mechanism that overloads the mitochondria.